Platycodin D2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Platycodin D2 是一种溶血性较低的皂苷，可改善小鼠对乙型肝炎表面抗原的特异性细胞和体液反应，可安全地用作引发 Th1 和 Th2 免疫反应的佐剂。

Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses.(In Vitro):Platycodin D2 exhibited significant inhibition on the proliferation of five kinds of cultured human tumor cell lines(ED50: ca. 4 - 18 microg/mL), i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.(In Vivo):Platycodin D2 significantly increased the concanavalin A (Con A)-, lipopolysaccharide (LPS)-, and HBsAg-induced splenocyte proliferation in HBsAg-immunized mice (P<0.05, P<0.01, and P<0.001, resp.). HBsAg-specific IgG, IgG1, IgG2a, and IgG2b antibody titers in the serum were also markedly enhanced by Platycodin D2 compared to the HBsAg control group (P<0.01 or P<0.001). Moreover, Platycodin D2 significantly promoted the production of Th1 (IL-2 and IFN-gamma) and Th2 (IL-4 and IL-10) cytokines from splenocytes in the HBsAg-immunized mice (P<0.001). The adjuvant potential of Platycodin D2 on splenocyte proliferation, serum HBsAg-specific IgG2a and IgG2b antibody response, as well as Th1-cytokine secretion from splenocytes in the HBsAg-immunized mice was higher than that of Alum.

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Apoptosis

IL Receptor

IL Receptor

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66663-90-9

1387.476

C63H102O33

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (72.07 mM)

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(-20℃)

With Ice Pack

≥ 2 years